Immunohistochemical Localization of Cadherin and Catenin Adhesion Molecules in the Murine Growth Plate

H. Wayne Sampson ^1*, Alaina C. Dearman ¹, Adebayo D. Akintola ¹, Warren E. Zimmer ¹ and Alan R. Parrish ¹

¹ Department of Systems Biology and Translational Medicine, Texas A & M Health Science Center-College of Medicine, College Station, Texas (HWS,ACD,ADA,WEZ,ARP), and Department of Orthopaedics, Center for Bone, Joint and Spine Research, Scott and White Hospital, Temple, Texas (HWS)

^* To whom correspondence should be addressed. E-mail: sampson{at}medicine.tamhsc.edu.

Submitted on January 10, 2007
Accepted on 26 March 2007

	Abstract

Mouse, tibial, growth plates were examined for the presence of adhesion molecules using immunohistochemistry and RT-PCR. All of the components of the classical cadherin/catenin complex (cadherin, -, -, and -catenin) as well as a heavy presence of p120 were identified in the murine growth plate. All of the major cadherins (1-5, 11, 13, and 15) were for the first time, identified and localized in the murine growth plate. We have demonstrated that most of the cadherins and catenins reside in the zone of hypertrophy. Only -catenin, E-, P-, and VE- cadherin were found in all regions of the growth plate. The results for T-cadherin are inconclusive.

Key Words: adhesion molecules, cadherins, catenins, bone, growth plate, signaling, hypertrophic zone

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