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JHC exPRESS: First Published July 11, 2007. doi:10.1369/jhc.7A7188.2007
Journal of Histochemistry and Cytochemistry
Copyright © 2007 Xin et al.

A more recent version of this article appeared on November 1, 2007.
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Articles

Septin Expression in Proliferative Retinal Membranes

Xiaorong Xin 1, Mona Pache 1, Barbara Zieger 1, Ingrid Bartsch 1, Christian Prünte 1, Josef Flammer 1 and Peter Meyer 1*

1 Department of Ophthalmic Pathology (XX,PM) and University Eye Clinic (CP,JF), University of Basel, Basel, Switzerland; Department of Ophthalmology, Qinghai Provincial People’s Hospital, Xining, Qinghai, China (XX); and University Eye Hospital (MP) and Department of Pediatrics and Adolescent Medicine (BZ,IB), University of Freiburg, Freiburg, Germany

* To whom correspondence should be addressed. E-mail: peter.meyer{at}unibas.ch.

Submitted on January 13, 2007
Accepted on 4 June 2007


  Abstract
The purpose of this study was to evaluate the expression of the septin family members SEPT5, SEPT8, and SEPT11 in proliferative retinal membranes. Epiretinal membranes were obtained from 7 patients with proliferative vitreoretinopathy (PVR), and from 4 patients and 4 postmortem eyes with proliferative diabetic retinopathy (PDR). Subretinal membranes (SRM) were obtained from 1 patient and 6 postmortem eyes. The membranes were examined by immunohistochemical staining of paraffin sections, using polyclonal antibodies against SEPT5, SEPT8 and SEPT11 and an ABC-detection system. SEPT8 expression was detected in all epi- and subretinal membranes, with an exceptionally strong expression of 100% for epiretinal PVR membranes, 63% for PDR membranes, and 57% for subretinal membranes. SEPT11 was identified in 91% of all cases, with strong expression of 14%, 25% and 14% in epiretinal PVR, PDR and SRM respectively. SEPT5 was seen in 50% of all cases; strong immunostaining was only found in one case of PVR membranes. Our finding suggests a role for members of the septin family in the development of proliferative retinal membranes.

Key Words: SEPT5, SEPT8, SEPT11, proliferative vitreoretinopathy, proliferative diabetic retinopathy, epiretinal membrane, subretinal membrane


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